How Marijuana Affects the Brain: Short and Long-Term Effects

26th February 2025

Marijuana is a topic that has sparked immense curiosity, debate, and research over the years. With increasing legalization and changing perceptions, it’s more important than ever to understand how marijuana affects the brain. For both recreational users and those considering cannabis for medical purposes, knowing what happens inside your head can help you make informed decisions.

This article dives into the science behind marijuana’s impact on the brain, exploring both the short-term effects and potential long-term consequences. Whether you’re new to cannabis or seeking to deepen your understanding, here’s an evidence-based look at how marijuana interacts with one of the most complex organs in our body. According to Healthcare professionals medical marijuana clinic, you should never use MMJ without approval of a certified cannabis physician. 

What Happens to the Brain When You Use Marijuana?

To understand marijuana’s effects, we must first look at how it interacts with the brain. Marijuana contains over 100 compounds, but the most well-known is tetrahydrocannabinol (THC). THC is the psychoactive compound responsible for the “high” people experience when using marijuana.

Our brain has a network known as the endocannabinoid system (ECS), which plays a vital role in regulating mood, memory, sleep, appetite, and more. The ECS consists of receptors, primarily CB1 receptors, located in several regions of the brain. THC mimics the natural chemicals (endocannabinoids) in our body and binds to CB1 receptors, disrupting normal communication within the ECS.

This disruption is what leads to both the immediate euphoric sensations and some of the long-term impacts that we’ll unpack below.

The Short-Term Effects of Marijuana on the Brain

For those curious about marijuana’s immediate effects, here’s a breakdown of what typically happens shortly after use.

1. Euphoria and Altered Perception

THC stimulates the brain’s reward system, releasing dopamine a chemical associated with pleasure. Users often report feelings of euphoria, relaxation, and a heightened sensory experience (like colors appearing brighter or music sounding more vivid). However, this altered perception can also distort time and space, contributing to feelings of disorientation.

2. Impaired Memory and Cognitive Function

The hippocampus, a part of the brain critical to forming new memories, is highly influenced by CB1 receptors. THC interferes with this region, making short-term memory recall more difficult. This is why marijuana users may struggle to retain information or participate in quick problem-solving while under the influence.

3. Anxiety or Paranoia

Not every user experiences marijuana as relaxing. For some, THC can heighten anxiety levels or induce paranoia, especially with high doses or for individuals predisposed to mental health challenges.

4. Reduced Motor Coordination

Areas of the brain like the cerebellum are affected by THC, leading to slower reaction times and impaired coordination. This is why driving or operating machinery after consuming marijuana is both illegal and dangerous.

5. Hunger (The Munchies)

Ever wondered why people crave snacks after smoking weed? THC activates brain regions associated with hunger, making food more appealing even when you’re not truly hungry.

The Long-Term Effects of Marijuana on the Brain

While short-term effects wear off after a few hours, regular or heavy marijuana use can lead to more lasting changes, especially in adolescents or frequent users.

1. Changes in Brain Development (For Adolescents)

During adolescence, the brain undergoes critical development, particularly in areas like the prefrontal cortex (responsible for decision-making, planning, and impulse control). Chronic marijuana use during this formative period can disrupt normal growth and wiring, potentially leading to long-term cognitive deficits.

  • Memory and Learning Impairment: Studies show that regular marijuana use during adolescence can result in lower scores on memory and learning tests, even years after cessation.
  • Reduced IQ: Some research indicates a small yet significant drop in IQ points among individuals who began heavy use in their teens.

2. Risk of Dependence

Contrary to popular belief, marijuana can be addictive for some individuals. Approximately 1 in 10 users y develop Cannabis Use Disorder (CUD), characterized by dependency and withdrawal symptoms. This risk increases for those who start using marijuana at a young age or use it frequently.

3. Mental Health Concerns

Chronic marijuana use has been linked to certain mental health conditions:

  • Depression and Anxiety: Heavy, long-term use might exacerbate symptoms of depression and anxiety for some individuals.
  • Psychosis: High doses of THC, particularly in genetically predisposed individuals, may increase the risk of psychotic disorders such as schizophrenia.

4. Structural Brain Changes

While the research is ongoing, some imaging studies suggest chronic marijuana use may lead to subtle changes in brain structure, particularly in regions like the amygdala (emotion processing) and hippocampus (memory).

5. Impaired Motivation

Some users may experience amotivation syndrome, a condition characterized by reduced interest in pursuing goals or engaging in daily activities. However, the existence of amotivation syndrome as a direct consequence of marijuana remains debated among experts.

Medicinal Marijuana and the Brain

It’s important to highlight that not all marijuana use is recreational. Many see significant benefits from medical marijuana, particularly when treated with CBD (cannabidiol)—a non-psychoactive compound in cannabis. Unlike THC, CBD doesn’t produce a high and is often used for its potential to:

  • Reduce chronic pain
  • Alleviate anxiety
  • Improve sleep
  • Manage epilepsy (as seen with FDA-approved drugs like Epidiolex)

However, even medicinal marijuana should be consumed under professional supervision to avoid unwanted side effects.

Balancing the Risks and Benefits

With marijuana becoming increasingly accessible, thanks to legalization in many regions, understanding its effects is crucial. For occasional users, the short-term impacts might be mild and fleeting. But for daily or adolescent users, the risks of long-term cognitive, emotional, and structural changes are worth considering. 

For those interested in cannabis for medicinal purposes, opting for strains low in THC and consulting with a healthcare provider can minimize potential harm.